Takeshi hosomi biography of abraham
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Abstract
Aim: There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men.
Methods: This was a cross-sectional survey of randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire; CAC by computed tomography; and carotid IMT by ultrasonography.
Results: The prevalence of CAC was % for participants with sleep duration < h, % with – h, % with – h, % with – h, and % with ≥ h. In univariate analysis, participants with sleep duration ≥ h had significantly higher prevalence of CAC than those with – h (p = ). After adjustment for age and other risk factors, however, the association was not significant (p = ). The average IMT was mm for participants with sleep duration < h, mm with – h, mm with – h, mm with – h, and mm with ≥ h. None of the differences in IMT observed in crude or multivariable-adjusted analyses was significant (all p > ).
Conclusion: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of J
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Seiun Award
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Role of stress and early-life stress in the pathogeny of inflammatory bowel disease
Introduction
Preclinical and clinical studies have shown that stress is one of the main environmental factor playing a significant role in the pathogeny and life-course of bowel diseases (Bonaz and Bernstein, ; Pellissier and Bonaz, ; Bernstein, ; Labanski et al., ). However, while today the place of stress, and particularly early life stress (ELS), is recognized in the pathogeny of functional digestive disorders such as irritable bowel syndrome (IBS) (Pellissier and Bonaz, ), this implication is still poorly studied in inflammatory bowel disease (IBD) and only recent clinical studies begin to bring some empiric arguments (Witges et al., ; Gnat et al., ; Minjoz et al., ). In this literature review, we propose to clarify the role of stress and ELS in IBD, in particular the mechanistic knowledge on the role and consequences of ELS in IBD, and propose therapeutic (either drug or non-drug) interventions. Previous reviews have focused mainly on the role of stress in IBD (Bonaz and Bernstein, ; Bernstein, ; Labanski et al., ) but not the role of ELS. Focusing on ELS as potential aggravating factors seems quite interesting because they may favor digestive, mental, and physical vulnerabilities in IBD